Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | J. Allen Josh Allen | M. Barkley Matt Barkley | |
| Running Back | D. Singletary Devin Singletary | T. Yeldon T.J. Yeldon | |
| Wide Receiver | S. Diggs Stefon Diggs | J. Brown John Brown | |
| Tight End | D. Knox Dawson Knox | L. Smith Lee Smith | |
| Left Tackle | D. Dawkins Dion Dawkins | T. Nsekhe Ty Nsekhe | — |
| Left Guard | I. Boettger Ike Boettger | J. Devey Jordan Devey | — |
| Center | M. Morse Mitch Morse | R. Bates Ryan Bates | — |
| Right Guard | B. Winters Brian Winters | J. Feliciano Jon Feliciano | — |
| Right Tackle | D. Williams Daryl Williams | — | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | J. Hughes Jerry Hughes | T. Murphy Trent Murphy | |
| Right Defensive End | M. Addison Mario Addison | A. Epenesa A.J. Epenesa | — |
| Left Defensive Tackle | Q. Jefferson Quinton Jefferson | V. Butler Vernon Butler | — |
| Right Defensive Tackle | E. Oliver Ed Oliver | H. Phillips Harrison Phillips | |
| Strongside Linebacker | A. Klein A.J. Klein | D. Lee Darron Lee | |
| Middle Linebacker | T. Edmunds Tremaine Edmunds | T. Matakevich Tyler Matakevich | |
| Weakside Linebacker | M. Milano Matt Milano | A. Smith Andre Smith | — |
| Right Cornerback | J. Norman Josh Norman | L. Wallace Levi Wallace | |
| Left Cornerback | T. White Tre'Davious White | T. Johnson Taron Johnson | |
| Strong Safety | J. Poyer Jordan Poyer | D. Marlowe Dean Marlowe | — |
| Free Safety | M. Hyde Micah Hyde | J. Johnson Jaquan Johnson | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | C. Bojorquez Corey Bojorquez | — | — |
| Kicker | T. Bass Tyler Bass | — | — |
| Long Snapper | R. Ferguson Reid Ferguson | — | — |
| Holder | C. Bojorquez Corey Bojorquez | — | — |
| Punt Returner | A. Roberts Andre Roberts | I. McKenzie Isaiah McKenzie | — |
| Kick Returner | A. Roberts Andre Roberts | I. McKenzie Isaiah McKenzie | — |