Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | B. Mayfield Baker Mayfield | C. Keenum Case Keenum | — |
| Running Back | N. Chubb Nick Chubb | K. Hunt Kareem Hunt | |
| Fullback | A. Janovich Andy Janovich | — | — |
| Wide Receiver | J. Landry Jarvis Landry | R. Higgins Rashard Higgins | |
| Tight End | A. Hooper Austin Hooper | H. Bryant Harrison Bryant | |
| Left Tackle | J. Wills Jedrick Wills | K. Lamm Kendall Lamm | — |
| Left Guard | — | B. Hance Blake Hance | — |
| Center | J. Tretter JC Tretter | — | — |
| Right Guard | W. Teller Wyatt Teller | — | — |
| Right Tackle | J. Conklin Jack Conklin | B. Hance Blake Hance | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | M. Garrett Myles Garrett | J. Jackson Joe Jackson | |
| Right Defensive End | A. Clayborn Adrian Clayborn | P. Gustin Porter Gustin | |
| Left Defensive Tackle | S. Richardson Sheldon Richardson | J. Elliott Jordan Elliott | — |
| Right Defensive Tackle | L. Ogunjobi Larry Ogunjobi | V. Taylor Vincent Taylor | — |
| Strongside Linebacker | S. Takitaki Sione Takitaki | J. Phillips Jacob Phillips | |
| Middle Linebacker | B. Goodson B.J. Goodson | J. Phillips Jacob Phillips | |
| Weakside Linebacker | M. Smith Malcolm Smith | M. Wilson Mack Wilson | — |
| Right Cornerback | T. Mitchell Terrance Mitchell | K. Johnson Kevin Johnson | |
| Left Cornerback | D. Ward Denzel Ward | M. Stewart M.J. Stewart | |
| Strong Safety | R. Harrison Ronnie Harrison | K. Joseph Karl Joseph | — |
| Free Safety | A. Sendejo Andrew Sendejo | S. Redwine Sheldrick Redwine |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. Gillan Jamie Gillan | — | — |
| Kicker | C. Parkey Cody Parkey | — | — |
| Long Snapper | C. Hughlett Charley Hughlett | — | — |
| Punt Returner | D. Peoples-Jones Donovan Peoples-Jones | D. Johnson D'Ernest Johnson | — |
| Kick Returner | D. Johnson D'Ernest Johnson | D. Peoples-Jones Donovan Peoples-Jones | — |