Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | B. Mayfield Baker Mayfield | G. Gilbert Garrett Gilbert | |
| Running Back | N. Chubb Nick Chubb | K. Hunt Kareem Hunt | |
| Wide Receiver | O. Beckham Odell Beckham | J. Landry Jarvis Landry | |
| Tight End | D. Njoku David Njoku | D. Harris Demetrius Harris | |
| Left Tackle | G. Robinson Greg Robinson | J. McCray Justin McCray | — |
| Left Guard | J. Bitonio Joel Bitonio | — | — |
| Center | J. Tretter JC Tretter | — | — |
| Right Guard | W. Teller Wyatt Teller | E. Kush Eric Kush | — |
| Right Tackle | C. Hubbard Chris Hubbard | K. Lamm Kendall Lamm | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | C. Thomas Chad Thomas | B. Cox Bryan Cox | |
| Right Defensive End | O. Vernon Olivier Vernon | P. Gustin Porter Gustin | — |
| Left Defensive Tackle | L. Ogunjobi Larry Ogunjobi | B. Bryant Brandin Bryant | — |
| Right Defensive Tackle | S. Richardson Sheldon Richardson | E. Ankou Eli Ankou | |
| Strongside Linebacker | A. Taylor Adarius Taylor | T. Davis Tae Davis | |
| Middle Linebacker | J. Schobert Joe Schobert | S. Takitaki Sione Takitaki | — |
| Weakside Linebacker | M. Wilson Mack Wilson | C. Kirksey Christian Kirksey | — |
| Right Cornerback | G. Williams Greedy Williams | T. Mitchell Terrance Mitchell | |
| Left Cornerback | D. Ward Denzel Ward | T. Carrie T.J. Carrie | |
| Strong Safety | J. Burris Juston Burris | E. Murray Eric Murray | |
| Free Safety | D. Randall Damarious Randall | S. Redwine Sheldrick Redwine | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. Gillan Jamie Gillan | — | — |
| Kicker | A. Seibert Austin Seibert | — | — |
| Long Snapper | C. Hughlett Charley Hughlett | — | — |
| Punt Returner | D. Hilliard Dontrell Hilliard | J. Landry Jarvis Landry | |
| Kick Returner | D. Hilliard Dontrell Hilliard | T. Thomas Tavierre Thomas |