Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | B. Mayfield Baker Mayfield | T. Taylor Tyrod Taylor | |
| Running Back | N. Chubb Nick Chubb | D. Johnson Duke Johnson | |
| Wide Receiver | J. Landry Jarvis Landry | A. Callaway Antonio Callaway | |
| Tight End | D. Njoku David Njoku | D. Fells Darren Fells | |
| Left Tackle | G. Robinson Greg Robinson | D. Harrison Desmond Harrison | — |
| Left Guard | J. Bitonio Joel Bitonio | A. Corbett Austin Corbett | |
| Center | J. Tretter JC Tretter | — | — |
| Right Guard | K. Zeitler Kevin Zeitler | E. Watford Earl Watford | — |
| Right Tackle | C. Hubbard Chris Hubbard | — | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | E. Ogbah Emmanuel Ogbah | A. Zettel Anthony Zettel | |
| Right Defensive End | M. Garrett Myles Garrett | C. Smith Chris Smith | |
| Left Defensive Tackle | T. Coley Trevon Coley | B. Price Brian Price | — |
| Strongside Linebacker | J. Collins Jamie Collins | D. Hines D'Juan Hines | |
| Middle Linebacker | J. Schobert Joe Schobert | R. Armstrong Ray-Ray Armstrong | — |
| Weakside Linebacker | G. Avery Genard Avery | T. Vallejo Tanner Vallejo | |
| Right Cornerback | T. Carrie T.J. Carrie | T. Thomas Tavierre Thomas | |
| Left Cornerback | D. Ward Denzel Ward | T. Mitchell Terrance Mitchell | |
| Strong Safety | J. Peppers Jabrill Peppers | D. Kindred Derrick Kindred | — |
| Free Safety | D. Randall Damarious Randall | B. Boddy-Calhoun Briean Boddy-Calhoun |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | B. Colquitt Britton Colquitt | — | — |
| Kicker | G. Joseph Greg Joseph | — | — |
| Long Snapper | C. Hughlett Charley Hughlett | — | — |
| Holder | B. Colquitt Britton Colquitt | — | — |
| Punt Returner | J. Peppers Jabrill Peppers | A. Callaway Antonio Callaway | — |
| Kick Returner | J. Peppers Jabrill Peppers | D. Hilliard Dontrell Hilliard | — |