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The MLB schedule on Wednesday, June 4 is loaded with 15 games and all 30 MLB teams scheduled to play. One of the most notable matchups in the late slate of games is Orioles vs. Mariners, where the SportsLine Projection Model is predicting a strong performance from Baltimore starter Cade Povich. The model is calling for Povich to go under 2.5 earned runs allowed on Wednesday night. Seattle is the -112 favorite (risk $112 to win $100) on the money line in the latest Wednesday MLB odds. 

Another notable late night matchup is Giants vs. Padres in a battle between NL West contenders. The Padres are -115 favorites on the money line, but SportsLine's model is backing the Giants ML at -104 (risk $104 to win $100). Before making any MLB picks or building any MLB parlay cards, you'll want to see the MLB predictions and betting advice from SportsLine's proven computer simulation model. You can also check out our MLB prop bet picks and MLB home run picks for Wednesday.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 11 of the 2025 MLB season on a profitable 13-10 run on top-rated MLB money-line betting picks. Anybody following at sportsbooks and on betting apps could have seen strong returns.

The model has broken down the MLB odds for Wednesday and just revealed its top picks and MLB player props. Combining the model's four picks into an MLB parlay would result in a payout of +1783 (risk $100 to win $1,783). New users can even take advantage of the DraftKings promo code offering $300 in bonus bets instantly with a $5 wager.

Here are its best bets for the MLB slate on Wednesday.

  • Jonah Heim over 0.5 total bases (-126)
  • Michael Harris II over 0.5 runs batted in (+197)
  • Cade Povich under 2.5 total earned runs allowed (-129)
  • San Francisco Giants moneyline (-106) vs. San Diego Padres
  • Combine these picks for a shot at a +1783 payout (odds subject to change)  

Jonah Heim over 0.5 total bases (-126)

Heim and the Rangers face the Tampa Bay Rays on Wednesday in the second game of their mid-week series. The 29-year-old is an above average offensive catcher, and is projected to finish with 1.0 total bases on Wednesday, according to SportsLine's model. The model gives this pick an edge of 0.5 based on the projection of 1.0 and the consensus line of 0.5.

Michael Harris II over 0.5 runs batted in (+197)

Harris is a streaky hitter, but faces a favorable matchup on Wednesday. The Braves host the Arizona Diamondbacks, and SportsLine's model is projecting 0.6 RBI for the 24-year-old centerfielder. Harris has gone over his total runs batted market in four of his last five games when the Braves have been favored and playing teams with a losing record, maintaining an average of 1.0 total runs batted in per game in those games.

Cade Povich under 2.5 earned runs allowed (-129)

Povich has battled some inconsistencies in 2025, but the underlying metrics suggest he could be in for a big performance on Wednesday. Most of Povich's issues have been due to control problems, byt the 25-year-old is averaging over nine strikeouts per inning pitched this season. SportsLine has an edge of 0.6 for this pick based on the projection of 1.9 and the consensus line of 2.5.

San Francisco Giants money line (-106) vs. San Diego Padres

Both teams in this matchup are legitimate postseason contenders and threats to the Los Angeles Dodgers in the National League West division. The Giants are 7-4 record (+107) as home underdogs this season. SportsLine's model is projecting a final score of 4.1-3.7 in San Francisco's favor, with the Giants winning in 59% of computer simulations.

Want more MLB picks for today?

You've seen some of the model's MLB best bets for Wednesday. Now, get run line, total and money-line picks for every game here, all from the model that's simulated every game 10,000 times. 

Also at SportsLine:
You can also see today's top MLB picks from expert Matt Severance, who's on a sizzling 137-70 roll on his last 207 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who's up more than 20 units.