caleb-williams.jpg
Imagn Images

The Detroit Lions (3-1) play against the Cincinnati Bengals (2-2) in Week 5 of the 2025 regular season. The Lions have won three straight games, including a 34-10 win over the Cleveland Browns last week. It's been tough for the Bengals since Joe Burrow went down with turf toe, as they've lost two consecutive games. On Sept. 29, the Broncos blew out Cincinnati 28-3. D.J. Reed (hamstring) is out for the Lions. 

Kickoff is set for 4:25 p.m. ET from Paycor Stadium in Cincinnati. The Lions are favored by 10.5 points in the latest Lions vs. Bengals odds at DraftKings Sportsbook, while the over/under for total points scored is 49.5. The Lions are -571 money line favorites, while the Bengals are +476 underdogs. Before making any Lions vs. Bengals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

New users can target the all-new DraftKings promo code, which offers $200 in bonus bets with a winning $5 wager:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has zoned in on Lions vs. Bengals. Here are several NFL odds and betting lines for Lions vs. Bengals:

Lions vs. Bengals spread

Detroit -10.5 at DraftKings Sportsbook

Lions vs. Bengals over/under

49.5 points

Lions vs. Bengals money line

Detroit -571, Cincinnati +476


Here are SportsLine model's best bets for Lions vs. Bengals:

  • Lions -10.5
  • Over 49.5 points

Lions -10.5

During this two-game win streak, the Lions have secured two double-digit wins. Detroit is 2-0 ATS after a win and 3-1 ATS in the regular season in 2025. In the two games that Jake Browning started for the Bengals this year, they have lost by at least 25 points. The model expects this trend to carry on in this outing and has the Lions covering the spread in 54% of simulations. 

Over 49.5 points

The Lions are currently sixth in the league in total offense (365), 10th in passing offense (226), sixth in rushing offense (139), and first in points per game (34.3). They have scored 34-plus points in three straight games, and receiver Amon-Ra St. Brown plays a major role in that. St. Brown is seventh in the NFL in receiving yards (307) and first in receiving touchdowns (6). Despite the Bengals' offensive shortcomings lately, they still have a collection of playmakers that feature Ja'Marr Chase, Tee Higgins, and Chase Brown. The Over hits in 52% of simulations, according to the SportsLine Projection Model.

Want more Week 5 NFL picks?

You've seen the model's Week 5 NFL best bets. Now, get against the spread, total and money-line picks for every Week 5 NFL game here, all from the model that's simulated every game 10,000 times.