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USATSI

The No. 4 Clemson Tigers will try to remain positioned to make another appearance in the College Football Playoff when they face the Notre Dame Fighting Irish on Saturday night. Clemson's biggest obstacle along its path to the CFP semifinals comes this weekend, as the Fighting Irish have won five of their last six games. Notre Dame has scored 40-plus points in three of its last four wins, including a 41-point outburst at then-No. 16 Syracuse last week.

Kickoff is set for 7:30 p.m. ET. The Tigers are 4-point favorites in the latest Clemson vs. Notre Dame odds from Caesars Sportsbook, while the over/under for total points scored is 43.5. Before entering any Notre Dame vs. Clemson picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Clemson. You can head to SportsLine to see its picks. Here are several college football odds for Clemson vs. Notre Dame:

  • Clemson vs. Notre Dame spread: Clemson -4
  • Clemson vs. Notre Dame over/under: 43.5 points
  • Clemson vs. Notre Dame money line: Notre Dame +162, Clemson -195
  • Clemson vs. Notre Dame picks: See picks here

Why Notre Dame can cover

Notre Dame has suffered a few disappointing losses this season, but it has also shown that it can beat ranked teams. The Fighting Irish have picked up wins over North Carolina, BYU and Syracuse, with two of those wins coming on the road. They also held a 10-3 lead over No. 2 Ohio State in their season opener, so they have faced a level of competition that has prepared them for this battle. 

Sophomore running back Audric Estime rushed 20 times for 123 yards and two touchdowns against Syracuse last week, while sophomore Logan Diggs added 20 carries for 85 yards and a score. The Fighting Irish will lean heavily on their rushing attack again on Saturday night, allowing them to control the pace of the game. Clemson has only faced one ranked team on the road this season, needing double overtime to get past then-No. 21 Wake Forest. Notre Dame comes into this game on a remarkable run over the last three seasons, covering the spread in 11 consecutive games during the month of November. 

Why Clemson can cover

Clemson is riding a 14-game winning streak coming into this matchup after beating Syracuse in Week 8. The Tigers had an extra week to prepare for Saturday night's game, as last week was their open date. Notre Dame had to go on the road to face a ranked opponent, so Clemson certainly has an advantage as far as the schedule is concerned.

The Fighting Irish have lost three of their last four games against Clemson, averaging just 11.7 points per game during those losses. Clemson running back Will Shipley has been shredding defenses in recent weeks, averaging 146.5 rushing yards over his last two games. The Tigers have had plenty of success in big games in recent years, giving them a mental edge in this matchup. 

How to make Clemson vs. Notre Dame picks

The model has simulated Notre Dame vs. Clemson 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

So who wins Clemson vs. Notre Dame? And which side of the spread hits in well over 60% of simulations? Visit SportsLine now to see which side of the Notre Dame vs. Clemson spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.