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After a taxing regular season that has been full of coronavirus cancellations and resulting complications, Championship Week has finally arrived in college football. In a rematch of a classic game that resulted in a 47-40 win for Notre Dame in overtime, the No. 2 Fighting Irish will take on the No. 3 Clemson Tigers in the ACC Championship Game with a spot in the College Football Playoff virtually guaranteed for the winner. Clemson has Trevor Lawrence back after COVID-19 kept him out of the first matchup and Clemson is the 10.5-point favorite in the Week 16 college football odds from William Hill Sportsbook.

Meanwhile, the Big Ten had to bend its own rules to put No. 4 Ohio State into the championship game against No. 14 Northwestern and the Buckeyes would love an impressive victory as they look to hold off No. 5 Texas A&M, No. 6 Iowa State and others for a CFP bid. The Buckeyes are favored by 18.5 in the Championship Week college football spreads, but should you back them in your college football best bets? Before locking anything in for Saturday's action, be sure to see the top Week 16 college football expert picks, predictions and best bets from Barrett Sallee.

Sallee is a true insider -- a CBS Sports analyst, SiriusXM host, Heisman voter and consistently one of the top CBS Sports experts picking games against the spread -- and his best bets have helped bring in huge returns. He debuted with SportsLine in 2017 and has delivered in a big way. 

He went 59-35-2 (63 percent, plus $2,037) on all his college football picks for SportsLine in 2019, and he also enters Week 16 of the 2020 college football season on a 67-39 streak on his best bets since the start of last year. Anybody who has been following him is way up.

Now, he has turned his attention to the Week 16 college football odds from William Hill and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of 6-1. Get his top college football picks now

Top Week 16 college football expert predictions

One of Sallee's top college football picks for Week 16: He likes the over 51 points when No. 5 Texas A&M travels to Knoxville to take on Tennessee in a noon ET kickoff on Saturday. The Aggies are hoping for an Ohio State or Clemson loss and a win over Tennessee to earn a spot in the College Football Playoff. But with both those teams favored by double-digits, they'll need to earn some style points with a big win if everybody else holds serve.

That means Texas A&M should be throttling up offensively and the Tennessee defense certainly wore down as the season went along after being put in a lot of bad spots by the offense. During their current six-game winning streak, the Aggies are averaging 35.0 points per game and the Volunteers gave up 34.8 points per game during their six-game losing streak prior to snapping it against Vanderbilt with a 42-17 win last week.

To make matters even better for over bettors, Tennessee has made some strides offensively in recent weeks. The Volunteers have averaged 446 yards per contest in their last three games. Quarterbacks Harrison Bailey and JT Shrout have injected just enough life into the passing game for them to be dangerous, and the Vols should be able to move the ball on the ground against an Aggies front that allowed 6.5 yards per carry two weeks ago against Auburn.

How to make Week 16 college football picks 

Sallee has also found two other college football picks he's high on, including a play on a line he thinks is about 15 points off. You can only see his picks at SportsLine.

What are the best bets for Week 16 of college football? And which line is way off? Visit SportsLine now to see Barrett Sallee's college football best bets, all from one of the top analysts in the nation who has crushed his picks for SportsLine.