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DeVonta Smith WR | PHI
Eagles' DeVonta Smith: Ruled out for Week 4
Smith (hamstring) has been ruled out for Sunday's contest against the Rams.
Smith gutted through a hamstring injury during the Eagles' Week 3 loss at Chicago, playing all 50 offensive snaps en route to six catches (on eight targets) for 65 yards. After Smith failed to practice Wednesday and Thursday, Tim McManus of ESPN.com reported that he was in danger of sitting out Week 4, which now has been confirmed. In Smith's absence, Dontayvion Wicks and Makai Lemon will be the primary wide receivers at the disposal of QB Jalen Hurts.
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Ladd McConkey WR | LAC
Chargers' Ladd McConkey: Returns to practice Friday
McConkey (foot) is at practice Friday, Kris Rhim of ESPN reports.
After failing to practice Thursday and being seen leaving the locker room with a limp, McConkey's presence Friday is a positive sign for his chances of suiting up Sunday against the Seahawks. It's been a disappointing season for the Los Angeles offenses as a whole, and that includes McConkey, who has already dealt with ribs and foot issues four weeks into the campaign.
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DJ Moore WR | BUF
Bills' DJ Moore: Cleared for Week 4
Moore (shoulder) was limited in Friday's practice but doesn't have an injury designation for Sunday's game against New England.
Moore is still managing the shoulder injury he sustained in Week 2 against the Lions. While he was limited in practice all week, the veteran wideout should play his normal allotment of snaps against the Patriots after pacing the team in routes and targets last Sunday against the Chargers.
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Puka Nacua WR | LAR
Rams' Puka Nacua: Set to play Sunday
Head coach Sean McVay said Nacua (hip) won't have an injury designation ahead of Sunday's game at Philadelphia, Adam Grosbard of The Orange County Register reports.
Nacua has missed the last two games due to a hip injury, but he's poised to return to action in Week 4 after taking part in all three practice sessions this week. McVay relayed to Sarah Barshop of ESPN.com on Friday that while Nacua "looked sharp" Thursday, the Rams are still honing in on exactly what kind of workload the wide receiver will be able to handle. In any case, fantasy managers can exhale now that Nacua again is available to game-day lineups.
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Justin Jefferson WR | MIN
Vikings' Justin Jefferson: Ruled out for Week 4
Jefferson (ankle) has been ruled out for Sunday's game versus the Dolphins.
Jefferson wasn't able to practice this week due to the ankle injury that forced him out of this past Sunday's win at Tampa Bay. His next chance to suit up will be Sunday, Oct. 11 at New Orleans, but considering the Vikings have a Week 6 bye, the team could exercise caution with its top wide receiver with the second half of the campaign in mind. In any case, Jordan Addison is poised to serve as Minnesota's top pass catcher in the short term, with fellow WR Jauan Jennings, TE T.J. Hockenson and RB Aaron Jones likely next up for targets from QB Kyler Murray.
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Justin Jefferson WR | MIN
Vikings' Justin Jefferson: Remains absent Friday
Jefferson (ankle) remained absent from Friday's practice, Kevin Seifert of ESPN.com reports.
Jefferson hasn't practiced at all this week after twisting his ankle seven snaps into last Sunday's game against the Bucs. It's looking likely that Jefferson will now miss Week 4 against Miami. If so, Jordan Addison, Jauan Jennings and Tai Felton should see the bulk of the wideout snaps for the Vikings.
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Keenan Allen WR | SF
Colts' Keenan Allen: Questionable for Week 4
Allen (groin) was listed as a non-participant for Friday's practice and is questionable for Sunday's game against the Commanders, Nathan Brown of The Indianapolis Star reports.
After logging a limited practice Thursday, Allen moved the wrong direction Friday with a DNP tag and now carries a questionable designation into Sunday's contest in London. That leaves the Colts' veteran wide receiver with some added uncertainty for Week 4 availability. If Allen is unable to go, the Colts will dip even deeper into their wideout depth with Alec Pierce (heel) already on the shelf for multiple weeks. Josh Downs and Tyler Warren would be in line to soak up most of the targets.
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Terry McLaurin WR | WAS
Commanders' Terry McLaurin: Added to injury report as questionable
McLaurin (hamstring) was added to the injury report Friday and is listed as questionable for Sunday's game against the Colts, Nicki Jhabvala of The Athletic reports.
McLaurin appears to have injured his hamstring in Friday's practice, which is rarely a good sign for a player's availability Sunday. If McLaurin is unable to go against the Colts, Stefon Diggs, Dyami Brown and rookie Antonio Williams would be in line to absorb most of the wideout work for the Commanders. With this game kicking off early Sunday morning in London, fantasy managers will have options to pivot off McLaurin should he be deemed inactive.
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DJ Moore WR | BUF
Bills' DJ Moore: Practicing in non-contact jersey Friday
Moore (shoulder) is practicing in a non-contact jersey Friday, Sal Capaccio of WGR Sports Radio 550 Buffalo reports.
Moore has been limited in practice all week, as he continues to deal with the shoulder injury he suffered in Week 2 against the Lions. The veteran wideout played through the issue last Sunday against the Charger and ran a team-high 23 routes while seeing 10 targets from Josh Allen. Assuming he didn't suffer a setback, Moore should be able to play Sunday against New England.
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Xavier Legette WR | CAR
Panthers' Xavier Legette: Ruled out for Week 4
Legette (knee) has been ruled out for Sunday night's game against the Lions, Alex Zietlow of The Charlotte Observer reports.
Legette will miss a second straight game, and with Jalen Coker (quadriceps) listed questionable, the Panthers could be forced to dip even deeper into their wide receiver depth after Brycen Tremayne and John Metchie played heavy snaps in Week 3 against Cleveland.