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A heated AFC South rivalry is set to renew on Sunday when the Indianapolis Colts host the Tennessee Titans at 1 p.m. ET. The Colts secured an impressive 34-17 victory over the Titans earlier this month. Indianapolis has won seven of its last 10 meetings against Tennessee. 

Both teams are 7-3; Indianapolis is 4-1 at home, while Tennessee is 3-1 on the road. Indianapolis is favored by three-points in the latest Colts vs. Titans odds from William Hill Sportsbook, and the over-under is set at 51.5. Before entering any Titans vs. Colts picks, you'll want to see the NFL predictions from the advanced computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,800 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 19-10 on top-rated NFL picks this season, returning almost $800. The model also enters Week 12 on an incredible 115-75 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Colts vs. Titans. You can head to SportsLine to see its picks. Here are several NFL betting lines for Titans vs. Colts:

  • Colts vs. Titans spread: Colts -3
  • Colts vs. Titans over-under: 51.5 points
  • Colts vs. Titans money line: Indianapolis -160, Tennessee +140

What you need to know about the Colts

The Colts are one of the most well balanced teams in the NFL. In fact, Indianapolis ranks first in total offense, averaging 414.9 yards per game this season. Quarterback Philip Rivers leads the charge for the Colts, having thrown for 2,683 yards, 14 touchdowns against eight interceptions. The veteran signal caller has also recorded three touchdown passes in three of his last five games. Indianapolis' defense, meanwhile, ranks second in the league in total defense, allowing just 298.1 yards per contest. 

The Colts have also fared well against the Titans at Lucas Oil Stadium over the years. Indianapolis has won 10 of its last 12 games at home against the Titans. In addition, the Colts are 8-3 against the spread in their last 11 meetings against an AFC South opponent. 

What you need to know about the Titans

Meanwhile, Tennessee won 30-24 over the Baltimore Ravens in overtime last week. Running back Derrick Henry rushed for 133 yards on 28 carries. He delivered the winning score with his 29-yard TD run in overtime. It was his sixth game with 100-plus rushing yards this season, most in the NFL. Henry is aiming for his third game in a row vs. Indianapolis with 100-plus rushing yards. He has 100-plus rushing yards in his last seven road games. Henry leads the NFL with 1,079 rush yards.

Ryan Tannehill has two-plus TD passes in six of his past seven games. He has seven TDs vs. one INT in six career games vs. the Colts. Tannehill is one of three quarterbacks with 20-plus TDs (22) and fewer than five INTs (four) this season. A.J. Brown has a TD catch in six of his past seven games. Kevin Byard had a season-high 10 tackles in the Week 10 meeting. Mike Vrabel has lost four of five matchups with the Colts. 

How to make Colts vs. Titans picks

The model has simulated Colts vs. Titans 10,000 times and the results are in. It leaning under on the total, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Titans vs. Colts? And which side of the spread has all the value? Visit SportsLine now to see which side of the Titans vs. Colts spread to jump on Sunday, all from the model that enters Week 12 of the NFL season on an incredible 115-75 roll.