Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | K. MurrayKyler Murray | C. McCoyColt McCoy | |
| Running Back | J. ConnerJames Conner | E. BenjaminEno Benjamin | |
| Wide Receiver | M. BrownMarquise Brown | A. GreenA.J. Green | |
| Tight End | Z. ErtzZach Ertz | T. McBrideTrey McBride | |
| Left Tackle | D. HumphriesD.J. Humphries | J. MilesJoshua Miles | |
| Left Guard | J. PughJustin Pugh | S. HarlowSean Harlow | |
| Center | R. HudsonRodney Hudson | — | — |
| Right Guard | W. HernandezWill Hernandez | J. MurrayJustin Murray | |
| Right Tackle | K. BeachumKelvin Beachum | J. JonesJosh Jones |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | J. WattJ.J. Watt | C. ThomasCameron Thomas | |
| Nose Tackle | R. LawrenceRashard Lawrence | L. FotuLeki Fotu | — |
| Right Defensive End | Z. AllenZach Allen | K. KekeKingsley Keke | |
| Left Inside Linebacker | Z. CollinsZaven Collins | N. VigilNick Vigil | |
| Right Inside Linebacker | I. SimmonsIsaiah Simmons | T. VallejoTanner Vallejo | |
| Strongside Linebacker | M. GoldenMarkus Golden | D. KennardDevon Kennard | |
| Weakside Linebacker | D. GardeckDennis Gardeck | M. SandersMyjai Sanders | |
| Right Cornerback | M. WilsonMarco Wilson | B. BordersBreon Borders | |
| Left Cornerback | B. MurphyByron Murphy | J. GladneyJeff Gladney | |
| Strong Safety | J. ThompsonJalen Thompson | D. ThompsonDeionte Thompson | |
| Free Safety | B. BakerBudda Baker | J. WigginsJames Wiggins |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | A. LeeAndy Lee | N. CooneyNolan Cooney | — |
| Kicker | M. PraterMatt Prater | — | — |
| Long Snapper | A. BrewerAaron Brewer | — | — |
| Holder | A. LeeAndy Lee | N. CooneyNolan Cooney | — |
| Punt Returner | R. MooreRondale Moore | — | — |
| Kick Returner | R. MooreRondale Moore | E. BenjaminEno Benjamin |