Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | K. Murray Kyler Murray | C. Streveler Chris Streveler | |
| Running Back | K. Drake Kenyan Drake | C. Edmonds Chase Edmonds | |
| Wide Receiver | D. Hopkins DeAndre Hopkins | C. Kirk Christian Kirk | |
| Tight End | D. Arnold Dan Arnold | M. Williams Maxx Williams | |
| Left Tackle | D. Humphries D.J. Humphries | J. Miles Joshua Miles | |
| Left Guard | J. Pugh Justin Pugh | M. Garcia Max Garcia | |
| Center | M. Cole Mason Cole | L. Gaillard Lamont Gaillard | — |
| Right Guard | J. Murray Justin Murray | J. Sweezy J.R. Sweezy | — |
| Right Tackle | K. Beachum Kelvin Beachum | J. Jones Josh Jones | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | Z. Allen Zach Allen | L. Fotu Leki Fotu | — |
| Nose Tackle | D. Peko Sr. Domata Peko Sr. | R. Lawrence Rashard Lawrence | |
| Right Defensive End | A. Blackson Angelo Blackson | — | — |
| Left Inside Linebacker | J. Hicks Jordan Hicks | T. Vallejo Tanner Vallejo | |
| Right Inside Linebacker | D. Campbell De'Vondre Campbell | I. Simmons Isaiah Simmons | |
| Strongside Linebacker | D. Kennard Devon Kennard | D. Gardeck Dennis Gardeck | |
| Weakside Linebacker | H. Reddick Haason Reddick | M. Golden Markus Golden | |
| Right Cornerback | D. Kirkpatrick Dre Kirkpatrick | B. Murphy Byron Murphy | |
| Left Cornerback | P. Peterson Patrick Peterson | K. Peterson Kevin Peterson | |
| Strong Safety | C. Banjo Chris Banjo | J. Thompson Jalen Thompson | |
| Free Safety | B. Baker Budda Baker | D. Thompson Deionte Thompson | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | A. Lee Andy Lee | — | — |
| Kicker | M. Nugent Mike Nugent | B. Maher Brett Maher | |
| Long Snapper | A. Brewer Aaron Brewer | — | — |
| Holder | A. Lee Andy Lee | — | — |
| Punt Returner | A. Isabella Andy Isabella | C. Kirk Christian Kirk | — |
| Kick Returner | C. Edmonds Chase Edmonds | A. Isabella Andy Isabella | — |