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James Cook III RB | BUF
Bills' James Cook: Shreds Lions defense in win
Cook rushed 21 times for 135 yards and a touchdown and brought in one of three targets for four yards in the Bills' 41-31 win over the Lions on Thursday.
Cook repeatedly gashed a Lions defense that came in with a reputation for being stingy against the run, more than atoning for a lackluster Week 1 showing against the Texans just four days earlier. The star running back rounded out his fantasy night with the final score of the high-scoring clash for the Bills, recording a one-yard touchdown run with just under three minutes remaining in the fourth quarter. Cook's multiple explosive runs throughout the night served as a reminder of why he earned such lofty draft status this summer, and he'll remain a critical component of a juggernaut Bills offense in a Week 3 home matchup against the Chargers on Sunday, Sept. 27.
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Jahmyr Gibbs RB | DET
Lions' Jahmyr Gibbs: Eclipses 100 total yards in loss
Gibbs rushed 16 times for 52 yards and brought in six of eight targets for 61 yards and a touchdown in the Lions' 41-31 loss to the Bills on Thursday.
Gibbs managed a 16-yard run among his 16 carries, yet he generally found running room at a premium over the course of the high-scoring loss. Game script also limited the star running back's opportunities on the ground somewhat, but Gibbs did make up for it to an extent with his work as a receiver. The fourth-year pro tied for second in receptions and also was the runner-up in receiving yards for the Lions on the night, and he added his first receiving touchdown of the season when he brought in an 11-yard laser from Jared Goff with just over five minutes remaining in the first half. Gibbs should have a chance at reverting to a larger workload on the ground in a Week 3 home matchup against the Jets on Sunday, Sept. 27.
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Samaje Perine RB | CIN
Bengals' Samaje Perine: Added to injury report
Perine (knee) was listed as a non-participant at the Bengals' practice Thursday.
Perine was added to the injury report with an apparent knee injury after opening the week without a listed practice status Wednesday. The running back turned five carries into 20 yards and reeled in all three of his targets for 30 yards during the team's 33-27 win over the Buccaneers in Week 1, but he may have suffered a knee injury at some point during the contest. Perine will have another chance to practice Friday, but if he can't go Sunday against Houston, Tahj Brooks would stand to operate as the team's primary backup option behind Chase Brown in Cincinnati's backfield.
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Tyrone Tracy Jr. RB | NYG
Giants' Tyrone Tracy: Healthy ahead of Week 2
Tracy (illness) did not appear on the Giants' injury report Thursday, Dan Salomone of the team's official site reports.
Tracy was dealing with an illness to open the week, but he now appears to be back to full health. The running back logged just two snaps with the offense Week 1 against the Cowboys, losing a fumble on his second and final carry of the contest. Tracy figures to once again operate as the No. 3 option in the backfield behind starter Cam Skattebo and top backup Devin Singletary during Monday night's contest against the Rams.
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DJ Giddens RB | IND
Colts' DJ Giddens: Dealing with knee issue
Giddens (knee) did not participate at practice Thursday.
Giddens was a healthy scratch in Week 1, so it seems he may have hurt his knee during practice Wednesday. He'll probably have to return to practice Friday to give himself a chance at suiting up Sunday at Kansas City.
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Ty Johnson RB | BUF
Bills' Ty Johnson: Inactive again in Week 2
Johnson (hamstring) is listed as inactive Thursday against the Lions.
Despite being listed as limited on all three of the Bills' Week 2 injury reports, Johnson will continue to don street clothes on game days due to a hamstring issue that has bothered him since at least Aug. 24. In Johnson's absence, Ray Davis will continue to garner RB reps that don't go to starter James Cook, while Frank Gore is on hand in case one of those two leaves the game for any reason.
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Kaelon Black RB | SF
49ers' Kaelon Black: Added to injury report
Black was limited at Thursday's practice due to a groin injury, Matt Maiocco of NBC Sports Bay Area reports.
Black did not show up on Wednesday's injury report, but he was unable to get a full session in a day later. The extent of his injury is uncertain, but his status will be updated again Friday when the 49ers release their final report before Sunday's matchup with the Dolphins.
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RJ Harvey RB | DEN
Broncos' RJ Harvey: Officially limited Thursday
Harvey (hamstring) was limited at Thursday's practice, Aric DiLalla of the Broncos' official site reports.
Harvey opened Week 2 prep with no listed activity on Wednesday's injury report due to a hamstring issue, but one day later he upgraded his workload enough to go down as a limited participant. Ultimately, Friday's practice report will unveil whether or not he heads into the weekend without a designation for Sunday's contest against the Jaguars. In Monday's loss at Kansas City, Harvey paced Denver's backfield with 26 offensive snaps (to J.K. Dobbins' 22), but Harvey managed just seven touches for 41 yards from scrimmage, while Dobbins turned eight carries into 36 yards.
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Frank Gore Jr. RB | BUF
Bills' Frank Gore: Elevated to active roster
The Bills elevated Gore from the practice squad to the active roster for Thursday's game versus Detroit.
With Ty Johnson (hamstring) unavailable for Sunday's 36-31 win over the Texans, Gore was elevated to the active roster for that contest. He logged 11 offensive snaps, though he finished with just one carry for three yards. Gore's workload likely won't be much different against the Lions, so his elevation from the practice squad is mostly for depth purposes and seems to strongly suggest Johnson is in line to miss another game Thursday.
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RJ Harvey RB | DEN
Broncos' RJ Harvey: Taking part in Thursday's practice
Harvey (hamstring) is present at practice Thursday, Zac Stevens of DNVR Sports reports.
Harvey was listed as a non-participant on Wednesday's practice estimate, but he's set to participate in at least some capacity now that Denver's actually holding practice Thursday. The 2025 second-round pick turned seven touches into 41 yards from scrimmage in Monday's loss to the Chiefs and got all four targets among Denver's running backs while J.K. Dobbins took most of the rushing work. Harvey's availability bears monitoring ahead of Sunday's matchup with the Jaguars.