The Jacksonville Jaguars will take on the Carolina Panthers at 1 p.m. ET on Sunday at Bank of America Stadium. It's the fourth start in the NFL career of Jaguars quarterback Gardner Minshew, who has a total of seven touchdowns and one interception through his first three games. The Panthers, meanwhile, are led by Kyle Allen, who's gone 2-0 as the starter this season for Carolina after Cam Newton was sidelined with a foot injury. Carolina is 2-2 overall and 0-2 at home, while Jacksonville is 2-2 overall and 1-1 on the road. Carolina is favored by three-points in the latest Jaguars vs. Panthers odds, while the Over-Under is set at 40. Before you make any Jaguars vs. Panthers picks and NFL predictions for Week 5, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on its top-rated NFL picks since its inception four years ago. It has nailed its recent top-rated NFL picks, entering Week 5 of the 2019 NFL schedule on a blistering 21-11 run that dates back to last season. It's also on an 83-54 roll on top-rated NFL picks that dates back to the 2017 season. And in Week 4, it nailed the Saints (+2.5) winning outright as underdogs against the Cowboys. The model also ranked in the Top 10 on NFLPickWatch for the third year in a row on straight-up NFL picks and beat more than 96 percent of CBS Sports office pool players. Anyone who has followed it is way up.

Now, it has simulated Jaguars vs. Panthers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

The model knows Jacksonville didn't have too much breathing room in its game with Denver last week, but the Jaguars still walked away with a 26-24 victory. Among those leading the charge for Jacksonville was running back Leonard Fournette, who rushed for a career-high 225 yards on 29 carries. Fournette wore down Denver's defense while Minshew carved the Broncos' secondary, completing 19 passes for 213 yards and two touchdowns. 

The Panthers, meanwhile, have to be feeling good after securing their second straight victory on the road. Allen completed 24-of-34 passes for 232 yards, while running back Christian McCaffrey recorded 179 all-purpose yards and a touchdown in Carolina's 16-10 victory over the Texans. 

Two offensive stats to keep in the back of your head while watching: The Jaguars are rolling into the matchup with the sixth-best rushing attack in the league, averaging 135.3 yards per game. On the other hand, the Panthers come into the game with the 11th-ranked scoring offense, averaging 23.8 points per contest. 

So who wins Panthers vs. Jaguars? And which side of the spread is hitting in over 50 percent of simulations? Visit SportsLine right now to see which side of the Jaguars vs. Panthers spread you need to jump on, all from the computer model that has crushed its NFL picks.