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It was a rousing start to the NFL season, and now half the teams are looking for their first victories. Another 14-game NFL schedule on Sunday includes several key division matchups, and the volume of games means a plethora of NFL prop bets. Rookie quarterbacks Mac Jones of the Patriots and Zach Wilson of the Jets will square off in an AFC East matchup as the teams seek their first victory. The Super Bowl champion Buccaneers will try to avoid the upset in an NFC South matchup with the Falcons, while AFC heavyweights Kansas City and Baltimore square off in an interdivisional matchup on Sunday Night Football. Which NFL player props should you target?

The Over-Under on passing yards for Tom Brady against the Falcons is 310.5 in the latest Week 2 NFL odds from Caesars Sportsbook. Chiefs quarterback Patrick Mahomes' passing yards Over-Under is 317.5, while counterpart Lamar Jackson's rushing total is 69.5. There are hundreds of other Week 2 NFL prop picks you can ponder, including attempts, big plays and defense. Before locking in any 2021 NFL Week 2 prop bets, be sure to check out the top NFL picks and predictions from NFL props expert Alex Selesnick.

Over the past two seasons, Selesnick (aka PropStarz) is up a whopping 116 units on NFL props and futures plays. For a $100 bettor, that's an $11,600 return. PropStarz specializes in NFL and NBA prop betting, where he implements a combination of research, statistical analysis and mathematical modeling. His background playing competitive poker, Scrabble and backgammon helped form the foundation of his sports betting approach. 

In Week 1, PropStarz went 4-1 on his picks, including Atlanta receiver Russell Gage to go under 55.5 yards (-115). The expert predicted Gage would have major difficulty adjusting to his new role as the No. 2 receiver and that the added attention would hinder his production. The result? Gage was invisible in Sunday's 32-6 loss to the Eagles, failing to gain separation and being targeted just once. He didn't catch that pass, and PropStarz cashed that bet with ease.

Now, after a deep dive into the available Week 2 NFL prop bets, PropStarz has found five more picks he loves. He's only sharing his expert NFL prop bet picks at SportsLine

Top Week 2 NFL player prop picks

One Week 2 NFL prop bet PropStarz is backing: Eagles rookie DeVonta Smith goes over 3.5 catches (-120) in Philly's matchup with the 49ers. The Heisman Trophy winner and 10th overall pick has regained his rapport with former Crimson Tide quarterback Jalen Hurts, and the pairing looked dangerous last week in a rout of the Falcons. They hooked up six times on eight targets, with Smith catching six balls for 71 yards and a touchdown.

The 49ers are favored by 3.5 points, but they allowed 430 yards to the Lions in last week's 41-33 victory, including 314 through the air. Both marks ranked 25th in the league, and now the secondary is without cornerback Jason Verrett, who suffered a torn ACL in Week 1. Smith is the clear No. 1 option for Hurts, and he should be a major part of the game plan. "I expect the volume to again be there," PropStarz told SportsLine.

How to make NFL player prop bets for Week 2

PropStarz has locked in four other Week 2 NFL prop picks, including calling for a star receiver to continue to falter as other options emerge around him. You can see which 2021 Week 2 NFL prop bets to jump on only at SportsLine.

What are the best 2021 Week 2 NFL prop bets you can make? And which players could help you cash in huge? Visit SportsLine now to see the best NFL Week 2 prop bets, all from the expert up 116 units the past two years, and find out.