Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | P. MahomesPatrick Mahomes | C. HenneChad Henne | |
| Running Back | C. Edwards-HelaireClyde Edwards-Helaire | R. JonesRonald Jones | |
| Fullback | M. BurtonMichael Burton | — | — |
| Wide Receiver | J. Smith-SchusterJuJu Smith-Schuster | M. HardmanMecole Hardman | |
| Tight End | T. KelceTravis Kelce | B. BellBlake Bell | |
| Left Tackle | O. BrownOrlando Brown | P. WanoghoPrince Tega Wanogho | |
| Left Guard | J. ThuneyJoe Thuney | N. AllegrettiNick Allegretti | |
| Center | C. HumphreyCreed Humphrey | D. WilliamsDarryl Williams | |
| Right Guard | T. SmithTrey Smith | D. KinnardDarian Kinnard | — |
| Right Tackle | A. WylieAndrew Wylie | L. NiangLucas Niang |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | G. KarlaftisGeorge Karlaftis | M. DannaMichael Danna | |
| Right Defensive End | F. ClarkFrank Clark | J. KaindohJoshua Kaindoh | |
| Left Defensive Tackle | D. NnadiDerrick Nnadi | T. WhartonTershawn Wharton | — |
| Right Defensive Tackle | C. JonesChris Jones | T. StallworthTaylor Stallworth | |
| Strongside Linebacker | W. Gay Jr.Willie Gay Jr. | S. CalhounShilique Calhoun | |
| Middle Linebacker | J. CarterJermaine Carter | L. ChenalLeo Chenal | |
| Weakside Linebacker | N. BoltonNick Bolton | D. HarrisDarius Harris | — |
| Right Cornerback | L. SneedL'Jarius Sneed | D. BakerDeandre Baker | |
| Left Cornerback | T. McDuffieTrent McDuffie | R. FentonRashad Fenton | |
| Strong Safety | J. ReidJustin Reid | B. CookBryan Cook | |
| Free Safety | J. ThornhillJuan Thornhill | D. BushDeon Bush |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | T. TownsendTommy Townsend | — | — |
| Kicker | H. ButkerHarrison Butker | — | — |
| Long Snapper | J. WinchesterJames Winchester | — | — |
| Holder | T. TownsendTommy Townsend | — | — |
| Punt Returner | M. HardmanMecole Hardman | — | — |
| Kick Returner | M. HardmanMecole Hardman | — | — |