Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | J. Goff Jared Goff | S. Mannion Sean Mannion | — |
| Running Back | T. Gurley Todd Gurley | M. Brown Malcolm Brown | |
| Wide Receiver | B. Cooks Brandin Cooks | R. Woods Robert Woods | |
| Tight End | T. Higbee Tyler Higbee | G. Everett Gerald Everett | |
| Left Tackle | A. Whitworth Andrew Whitworth | — | — |
| Center | J. Sullivan John Sullivan | B. Allen Brian Allen | — |
| Right Guard | A. Blythe Austin Blythe | — | — |
| Right Tackle | R. Havenstein Rob Havenstein | — | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | M. Brockers Michael Brockers | M. Fox Morgan Fox | — |
| Nose Tackle | N. Suh Ndamukong Suh | S. Joseph-Day Sebastian Joseph-Day | — |
| Right Defensive End | A. Donald Aaron Donald | E. Westbrooks Ethan Westbrooks | |
| Left Inside Linebacker | C. Littleton Cory Littleton | B. Hager Bryce Hager | |
| Right Inside Linebacker | M. Barron Mark Barron | R. Wilson Ramik Wilson | — |
| Strongside Linebacker | D. Fowler Dante Fowler | M. Longacre Matt Longacre | |
| Weakside Linebacker | S. Ebukam Samson Ebukam | J. Franklin-Myers John Franklin-Myers | |
| Right Cornerback | S. Shields Sam Shields | N. Robey-Coleman Nickell Robey-Coleman | |
| Left Cornerback | M. Peters Marcus Peters | T. Hill Troy Hill | |
| Strong Safety | J. Johnson John Johnson | B. Countess Blake Countess | — |
| Free Safety | L. Joyner Lamarcus Joyner | M. Christian Marqui Christian | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. Hekker Johnny Hekker | — | — |
| Kicker | G. Zuerlein Greg Zuerlein | — | — |
| Long Snapper | J. McQuaide Jake McQuaide | J. Mundt Johnny Mundt | — |
| Holder | J. Hekker Johnny Hekker | — | — |
| Punt Returner | J. Natson JoJo Natson | — | — |
| Kick Returner | J. Natson JoJo Natson | — | — |