Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | J. Goff Jared Goff | J. Wolford John Wolford | |
| Running Back | C. Akers Cam Akers | M. Brown Malcolm Brown | |
| Wide Receiver | R. Woods Robert Woods | C. Kupp Cooper Kupp | |
| Tight End | T. Higbee Tyler Higbee | G. Everett Gerald Everett | |
| Left Tackle | J. Noteboom Joe Noteboom | T. Anchrum Tremayne Anchrum | — |
| Left Guard | C. Shelton Coleman Shelton | — | — |
| Center | A. Blythe Austin Blythe | B. Allen Brian Allen | — |
| Right Guard | A. Corbett Austin Corbett | D. Edwards David Edwards | — |
| Right Tackle | R. Havenstein Rob Havenstein | B. Evans Bobby Evans | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | M. Brockers Michael Brockers | M. Fox Morgan Fox | — |
| Nose Tackle | S. Joseph-Day Sebastian Joseph-Day | G. Gaines Greg Gaines | |
| Right Defensive End | A. Donald Aaron Donald | J. Williams Jonah Williams | — |
| Left Inside Linebacker | M. Kiser Micah Kiser | — | — |
| Right Inside Linebacker | T. Reeder Troy Reeder | K. Young Kenny Young | |
| Strongside Linebacker | L. Floyd Leonard Floyd | O. Okoronkwo Obo Okoronkwo | |
| Weakside Linebacker | S. Ebukam Samson Ebukam | J. Hollins Justin Hollins | |
| Right Cornerback | J. Ramsey Jalen Ramsey | D. Long David Long | |
| Left Cornerback | T. Hill Troy Hill | D. Williams Darious Williams | — |
| Strong Safety | J. Fuller Jordan Fuller | J. Hughes JuJu Hughes | |
| Free Safety | J. Johnson John Johnson | N. Scott Nick Scott |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. Hekker Johnny Hekker | — | — |
| Long Snapper | J. McQuaide Jake McQuaide | — | — |
| Holder | J. Hekker Johnny Hekker | — | — |
| Punt Returner | N. Webster Nsimba Webster | C. Kupp Cooper Kupp | — |
| Kick Returner | N. Webster Nsimba Webster | D. Henderson Darrell Henderson | — |