The Week 7 college football schedule will feature several top Heisman contenders facing tough tests. The latest Week 7 college football odds show No. 5 LSU and quarterback Joe Burrow as 13.5-point favorites against No. 7 Florida. Burrow has put up eye-popping numbers this season, but hasn't seen a defense like Florida's. Should the Tigers be among your top college football picks on Saturday? Both quarterbacks in the 2019 Red River Showdown, Jalen Hurts and Sam Ehlinger, have gotten Heisman buzz this season, and the latest Week 7 college football lines have Oklahoma vs. Texas going off with an over-under of 75.5 points, meaning there should be plenty of opportunities for them to pile up more huge stats. Before studying the college football spreads and making your picks, be sure to see the college football predictions from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed it have seen huge returns. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,300 for $100 players on its top-rated college football against-the-spread picks.  

The model enters Week 7 of the 2019 season on a strong run, going 68-42 on its top-rated college football picks. It also called Georgia (-27.5) covering against Tennessee and California (+21) easily staying within the spread against Oregon last week. Anybody who has been following it is way up. Now, its Week 7 college football predictions are in. 

One of the Week 7 college football picks the model is recommending: No. 9 Notre Dame (-10.5) covers at home against USC in a 7:30 p.m. ET matchup on Saturday in South Bend.

The Fighting Irish are 4-1 against the spread this season, and they covered a huge 45.5-point line against Bowling Green last week. The Trojans, meanwhile, have dropped two of three straight-up and are just 2-3 against the spread this season. The model is calling for Notre Dame quarterback Ian Book to throw for around 250 yards and two touchdowns as the Irish cover in 60 percent of simulations. 

Another one of the 2019 Week 7 college football predictions from the model: Kentucky (-6.5) covers at home against Arkansas in an SEC matchup at Kroger Field. 

Arkansas has been one of the worst teams in the SEC this season. The Razorbacks have won just one game against FBS competition and barely survived against FCS-level Presbyterian in Week 1.

Kentucky has struggled recently as well, but is hoping to have quarterback Sawyer Smith close to 100 percent after he struggled with multiple injuries (wrist, shoulder) in an ineffective game against South Carolina his last time out. The model projects that Smith throws for over 200 yards as the Wildcats cover in well over 60 percent of simulations. The under (53.5) also carries plenty of value because that hits in well over 50 percent of simulations. 

The model also has made the call on every other FBS matchup in Week 7, including the top-10 showdown between No. 7 Florida and No. 5 LSU, and is calling for a national title contender to go down hard this week. You should see its college football picks before locking in any selections of your own. 

So what college football picks can you make with confidence in Week 7? And which national title contender goes down hard? Check out the latest Week 7 college football odds below, and then visit SportsLine to see which teams are winning more than 50 percent of simulations, all from a proven computer model that has returned over $4,300 in profit over the past four seasons.

Toledo at Bowling Green (+25.5, 64.5)
Oklahoma vs. Texas (+11, 76)
Memphis at Temple (+5.5, 50)
South Carolina at Georgia (-24, 52.5)
Mississippi State at Tennessee (+7, 52.5)
Georgia Tech at Duke (-17.5, 49)
Washington State at Arizona State (PK, 59)
Cincinnati at Houston (+7.5, 51.5)
Michigan State at Wisconsin (-10.5, 40.5)
Alabama at Texas A&M (+17, 61)
Florida State at Clemson (-27, 60)
Iowa State at West Virginia (+10, 53)
Nebraska at Minnesota (-7.5, 50)
Louisville at Wake Forest (-6.5, 64.5)
USC at Notre Dame (-10.5, 59)
Penn State at Iowa (+3.5, 41.5)
Utah at Oregon State (+14, 59.5)
Florida at LSU (-13.5, 56)
Hawaii at Boise State (-12.5, 60)