Regular Season
| Date | OPP | Time / TV | Venue | Buy Tickets |
|---|---|---|---|---|
| Oct 12, 2021 | @ | Amalie Arena | ||
| Oct 14, 2021 | @ | BB&T Center | ||
| Oct 16, 2021 | vs | PPG Paints Arena | ||
| Oct 19, 2021 | vs | PPG Paints Arena | ||
| Oct 23, 2021 | vs | PPG Paints Arena | ||
| Oct 26, 2021 | vs | PPG Paints Arena | ||
| Oct 28, 2021 | vs | PPG Paints Arena | ||
| Oct 30, 2021 | vs | PPG Paints Arena | ||
| Nov 4, 2021 | vs | PPG Paints Arena | ||
| Nov 6, 2021 | vs | PPG Paints Arena | ||
| Nov 9, 2021 | @ | United Center | ||
| Nov 11, 2021 | vs | PPG Paints Arena | ||
| Nov 13, 2021 | @ | Canadian Tire Centre | ||
| Nov 14, 2021 | @ | Capital One Arena | ||
| Nov 16, 2021 | vs | PPG Paints Arena | ||
| Nov 18, 2021 | @ | Bell Centre | ||
| Nov 20, 2021 | @ | Scotiabank Arena | ||
| Nov 22, 2021 | @ | Bell MTS Place | ||
| Nov 24, 2021 | vs | PPG Paints Arena | ||
| Nov 26, 2021 | @ | UBS Arena | ||
| Nov 27, 2021 | vs | PPG Paints Arena | ||
| Nov 29, 2021 | @ | Scotiabank Saddledome | ||
| Dec 1, 2021 | @ | Rogers Place | ||
| Dec 4, 2021 | @ | Rogers Arena | ||
| Dec 6, 2021 | @ | Climate Pledge Arena | ||
| Dec 10, 2021 | @ | Capital One Arena | ||
| Dec 11, 2021 | vs | PPG Paints Arena | ||
| Dec 14, 2021 | vs | PPG Paints Arena | ||
| Dec 17, 2021 | vs | PPG Paints Arena | ||
| Dec 19, 2021 | @ | Prudential Center | ||
| Dec 21, 2021 | vs | PPG Paints Arena | ||
| Dec 23, 2021 | vs | PPG Paints Arena | ||
| Dec 27, 2021 | @ | TD Garden | ||
| Dec 29, 2021 | @ | Scotiabank Arena | ||
| Dec 31, 2021 | @ | Canadian Tire Centre | ||
| Jan 2, 2022 | vs | PPG Paints Arena | ||
| Jan 5, 2022 | vs | PPG Paints Arena | ||
| Jan 6, 2022 | @ | Wells Fargo Center | ||
| Jan 8, 2022 | @ | American Airlines Center | ||
| Jan 11, 2022 | @ | Honda Center | ||
| Jan 13, 2022 | @ | Staples Center | ||
| Jan 15, 2022 | @ | SAP Center at San Jose | ||
| Jan 17, 2022 | @ | T-Mobile Arena | ||
| Jan 20, 2022 | vs | PPG Paints Arena | ||
| Jan 21, 2022 | @ | Nationwide Arena | ||
| Jan 23, 2022 | vs | PPG Paints Arena | ||
| Jan 25, 2022 | vs | PPG Paints Arena | ||
| Jan 27, 2022 | vs | PPG Paints Arena | ||
| Jan 28, 2022 | vs | PPG Paints Arena | ||
| Jan 30, 2022 | vs | PPG Paints Arena | ||
| Feb 1, 2022 | vs | PPG Paints Arena | ||
| Feb 24, 2022 | @ | Prudential Center | ||
| Feb 26, 2022 | vs | PPG Paints Arena | ||
| Feb 27, 2022 | @ | Nationwide Arena | ||
| Mar 3, 2022 | @ | Amalie Arena | ||
| Mar 4, 2022 | @ | PNC Arena | ||
| Mar 8, 2022 | vs | PPG Paints Arena | ||
| Mar 10, 2022 | @ | UBS Arena | ||
| Mar 11, 2022 | vs | PPG Paints Arena | ||
| Mar 13, 2022 | vs | PPG Paints Arena | ||
| Mar 15, 2022 | @ | Bridgestone Arena | ||
| Mar 17, 2022 | @ | Enterprise Center | ||
| Mar 19, 2022 | @ | Gila River Arena | ||
| Mar 22, 2022 | vs | PPG Paints Arena | ||
| Mar 23, 2022 | @ | KeyBank Center | — | |
| Mar 25, 2022 | @ | Madison Square Garden | ||
| Mar 27, 2022 | vs | PPG Paints Arena | ||
| Mar 29, 2022 | vs | PPG Paints Arena | ||
| Mar 31, 2022 | @ | Xcel Energy Center | — | |
| Apr 2, 2022 | @ | Ball Arena | ||
| Apr 5, 2022 | vs | PPG Paints Arena | ||
| Apr 7, 2022 | @ | Madison Square Garden | — | |
| Apr 9, 2022 | vs | PPG Paints Arena | ||
| Apr 10, 2022 | vs | PPG Paints Arena | ||
| Apr 12, 2022 | vs | PPG Paints Arena | ||
| Apr 14, 2022 | vs | PPG Paints Arena | ||
| Apr 16, 2022 | @ | TD Garden | ||
| Apr 21, 2022 | vs | PPG Paints Arena | ||
| Apr 23, 2022 | @ | Little Caesars Arena | ||
| Apr 24, 2022 | @ | Wells Fargo Center | ||
| Apr 26, 2022 | vs | PPG Paints Arena | ||
| Apr 29, 2022 | vs | PPG Paints Arena |
