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The Denver Broncos will take on the Tampa Bay Buccaneers at 4:25 p.m. ET on Sunday at Empower Field at Mile High. Denver is 0-2 and Tampa Bay is 1-1. Tampa Bay is favored by 5.5 points in the latest Broncos vs. Buccaneers odds from William Hill, and the over-under is set at 42.5. Before entering any Buccaneers vs. Broncos picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,300 for $100 players on its top-rated NFL picks since its inception five-plus years ago. It's off to a strong 5-2 roll on top-rated NFL picks this season. The model enters Week 3 on an incredible 101-67 roll on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Broncos vs. Bucs. You can head to SportsLine to see its picks. Here are several NFL betting lines for Bucs vs. Broncos:

  • Broncos vs. Buccaneers spread: Broncos +6
  • Broncos vs. Buccaneers over-under: 42.5 points
  • Broncos vs. Buccaneers money line: Denver +220, Tampa Bay -260

What you need to know about the Broncos

The Broncos lost 26-21 to the Pittsburgh Steelers this past Sunday. Playing in place of the injured Drew Lock, Jeff Driskel passed for 256 yards and two TDs and one interception in his Denver debut. He has nine passing TDs vs. six INTs in eight career starts. Melvin Gordon led the team with 84 scrimmage yards and had a TD catch. Noah Fant is one of three NFL tight ends with a TD catch in each game so far. 

Rookie wide receiver Jerry Jeudy (ribs) will be a game-time decision. Lock (shoulder) will be out again and Phillip Lindsay (toe) is doubtful. Courtland Sutton (knee) is out for the season. 

What you need to know about the Buccaneers

Meanwhile, Tampa Bay scored a 31-17 win over the Carolina Panthers this past Sunday. Leonard Fournette rushed for two TDs and 103 yards on 12 carries. Mike Evans led the team with seven receptions for 104 yards and a TD catch in Week 2. He is one of three NFC wide receivers with a TD catch in each of the first two weeks. 

Tampa Bay's defensive front registered five sacks against Carolina. Lavonte David had nine tackles, a forced fumble and a fumble recovery in Week 2. Tom Brady has three-plus TD passes in four of his past five starts vs. Denver. 

How to make Buccaneers vs. Broncos picks

SportsLine's model has simulated Broncos vs. Buccaneers 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Buccaneers vs. Broncos? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the Buccaneers vs. Broncos spread to jump on Sunday, all from the model that enters Week 3 of the NFL season on an incredible 101-67 roll.