College football odds and picks for Week 6: Advanced model loving Ohio St., Penn St.

Our computer model simulated every Week 6 college football game 10,000 times with surprising results

College football's sixth weekend will attract bets from average Joes to professional bettors.

No. 8 TCU is favored by 13.5 against No. 23 West Virginia, No. 1 Alabama travels to 4-1 Texas A&M as a 26.5-point favorite and No. 7 Michigan is favored by 10 at home against arch-rival Michigan State in a game that has already seen the line move several points.

With so many eye-popping games and so many odds on the move, you'll want to know to what SportsLine's advanced computer model is picking.

SportsLine's Projection Model turned in double-digit profitable weeks in college football last season across all picks, including a remarkable 18-4 run on straight-up picks to open the season. Anyone who followed it during those weeks profited big. And it's fresh off a week in which it called LSU struggling against Troy and Ohio State continuing to cover huge spreads.

This week, the model simulated every Top 25 game, plus the rest of the slate, and the results were surprising. 

The model is once again loving Ohio State, this time to cruise past Maryland 49-11. The Buckeyes are 4-1 against the spread this season, and will easily cover a huge 31-point line Saturday. Expect the over to hit as well. The model is predicting a huge day for J.T. Barrett -- 21 of 34, 268 yards, and three touchdowns. Look for RB J.K. Dobbins to go over 100 yards and score.

The model is also all-in on Penn State, even on the road at Northwestern. The Nittany Lions are 13.5-point favorites, but the model is calling for a blowout 38-17. Penn State is winning a whopping 87 percent of simulations. Look for Trace McSorley to hit 300 yards passing and Saquon Barkley to top 100 yards on the ground for Penn State.

One huge shocker: TCU, favored by two touchdowns against West Virginia, only wins by four. Vegas is greatly underestimating the Mountaineers, who have beaten their past three opponents by an average of 33 points. Back West Virginia against the spread with confidence.

Another stunner: The nation's No. 2 team, Clemson, beats Wake Forest, but the score will be much closer than you think. Clemson is favored by three touchdowns, but the model is calling for a 29-14 Clemson victory. The Demon Deacons were 4-0 before dropping last week's game against Florida State. They are 3-1 against the spread this season.

It's also calling for a Top 25 team with high hopes to go down in flames, potentially wrecking its national championship bid in the process.

What college football picks can you make with confidence in Week 6? Check out the college football odds below and then visit SportsLine to see which teams are winning more than 50 percent of simulations, plus see which side of the big Michigan-Michigan State game is a virtual lock, all from the model that turned in double-digit winning weeks last season, as well as picks from 16 experts.

Alabama at Texas A&M (+26.5, 55)
Wake Forest at Clemson (-21.5, 47.5)
Iowa State at Oklahoma (-30, 63.5)
Penn State at Northwestern (+13.5, 50.5)
Georgia at Vanderbilt (+17, 41)
California at Washington (-28.5, 52)
Michigan State at Michigan (-10, 40.5)
West Virginia at TCU (-13.5, 67.5)
Wisconsin at Nebraska (10.5, 45.5)
Maryland at Ohio State (-31, 60.5)
Washington State at Oregon 34 (+2.5, 60.5)
Ole Miss at Auburn (-22.5, 57)
Miami at Florida State (+3, 46)
Oregon State at USC (-34, 59)
Virginia Tech at Boston College (+16.5, 45.5)
San Diego State at UNLV (9.5, 57)
Stanford at Utah (+4, 51)
Notre Dame at North Carolina (+15.5, 62.5)
LSU at Florida (-2.5, 45)