Regular Season
| Date | OPP | Time / TV | Venue | Home Starter | Away Starter | Buy Tickets |
|---|---|---|---|---|---|---|
| Apr 1, 2021 | vs | Comerica Park | — | — | — | |
| Apr 3, 2021 | vs | Comerica Park | — | — | — | |
| Apr 4, 2021 | vs | Comerica Park | — | — | — | |
| Apr 5, 2021 | vs | Comerica Park | — | — | — | |
| Apr 6, 2021 | vs | Comerica Park | — | — | — | |
| Apr 7, 2021 | vs | Comerica Park | — | — | — | |
| Apr 9, 2021 | @ | Progressive Field | — | — | — | |
| Apr 10, 2021 | @ | Progressive Field | — | — | — | |
| Apr 11, 2021 | @ | Progressive Field | — | — | — | |
| Apr 12, 2021 | @ | Minute Maid Park | — | — | — | |
| Apr 13, 2021 | @ | Minute Maid Park | — | — | — | |
| Apr 14, 2021 | @ | Minute Maid Park | — | — | — | |
| Apr 15, 2021 | @ | RingCentral Coliseum | — | — | — | |
| Apr 16, 2021 | @ | RingCentral Coliseum | — | — | — | |
| Apr 17, 2021 | @ | RingCentral Coliseum | — | — | — | |
| Apr 18, 2021 | @ | RingCentral Coliseum | — | — | — | |
| Apr 20, 2021 | vs | Comerica Park | — | — | — | |
| Apr 21, 2021 | vs | Comerica Park | — | — | — | |
| Apr 22, 2021 | vs | Comerica Park | — | — | — | |
| Apr 23, 2021 | vs | Comerica Park | — | — | — | |
| Apr 24, 2021 | vs | Comerica Park | — | — | — | |
| Apr 25, 2021 | vs | Comerica Park | — | — | — | |
| Apr 26, 2021 | vs | Comerica Park | — | — | — | |
| Apr 27, 2021 | @ | Guaranteed Rate Field | — | — | — | |
| Apr 28, 2021 | @ | Guaranteed Rate Field | — | — | — | |
| Apr 29, 2021 | @ | Guaranteed Rate Field | — | — | — | |
| Apr 30, 2021 | @ | Yankee Stadium | — | — | — | |
| May 1, 2021 | @ | Yankee Stadium | — | — | — | |
| May 2, 2021 | @ | Yankee Stadium | — | — | — | |
| May 4, 2021 | @ | Fenway Park | — | — | — | |
| May 5, 2021 | @ | Fenway Park | — | — | — | |
| May 6, 2021 | @ | Fenway Park | — | — | — | |
| May 7, 2021 | vs | Comerica Park | — | — | — | |
| May 8, 2021 | vs | Comerica Park | — | — | — | |
| May 9, 2021 | vs | Comerica Park | — | — | — | |
| May 11, 2021 | vs | Comerica Park | — | — | — | |
| May 12, 2021 | vs | Comerica Park | — | — | — | |
| May 13, 2021 | vs | Comerica Park | — | — | — | |
| May 14, 2021 | vs | Comerica Park | — | — | — | |
| May 15, 2021 | vs | Comerica Park | — | — | — | |
| May 16, 2021 | vs | Comerica Park | — | — | — | |
| May 17, 2021 | @ | T-Mobile Park | — | — | — | |
| May 18, 2021 | @ | T-Mobile Park | — | — | — | |
| May 19, 2021 | @ | T-Mobile Park | — | — | — | |
| May 21, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| May 22, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| May 23, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| May 24, 2021 | vs | Comerica Park | — | — | — | |
| May 25, 2021 | vs | Comerica Park | — | — | — | |
| May 26, 2021 | vs | Comerica Park | — | — | — | |
| May 27, 2021 | vs | Comerica Park | — | — | — | |
| May 28, 2021 | vs | Comerica Park | — | — | — | |
| May 29, 2021 | vs | Comerica Park | — | — | — | |
| May 30, 2021 | vs | Comerica Park | — | — | — | |
| May 31, 2021 | @ | Miller Park | — | — | — | |
| Jun 1, 2021 | @ | Miller Park | — | — | — | |
| Jun 3, 2021 | @ | Guaranteed Rate Field | — | — | — | |
| Jun 4, 2021 | @ | Guaranteed Rate Field | — | — | — | |
| Jun 5, 2021 | @ | Guaranteed Rate Field | — | — | — | |
| Jun 6, 2021 | @ | Guaranteed Rate Field | — | — | — | |
| Jun 8, 2021 | vs | Comerica Park | — | — | — | |
| Jun 9, 2021 | vs | Comerica Park | — | — | — | |
| Jun 10, 2021 | vs | Comerica Park | — | — | — | |
| Jun 11, 2021 | vs | Comerica Park | — | — | — | |
| Jun 12, 2021 | vs | Comerica Park | — | — | — | |
| Jun 13, 2021 | vs | Comerica Park | — | — | — | |
| Jun 14, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| Jun 15, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| Jun 16, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| Jun 17, 2021 | @ | Angel Stadium of Anaheim | — | — | — | |
| Jun 18, 2021 | @ | Angel Stadium of Anaheim | — | — | — | |
| Jun 19, 2021 | @ | Angel Stadium of Anaheim | — | — | — | |
| Jun 20, 2021 | @ | Angel Stadium of Anaheim | — | — | — | |
| Jun 22, 2021 | vs | Comerica Park | — | — | — | |
| Jun 23, 2021 | vs | Comerica Park | — | — | — | |
| Jun 24, 2021 | vs | Comerica Park | — | — | — | |
| Jun 25, 2021 | vs | Comerica Park | — | — | — | |
| Jun 26, 2021 | vs | Comerica Park | — | — | — | |
| Jun 27, 2021 | vs | Comerica Park | — | — | — | |
| Jun 28, 2021 | @ | Progressive Field | — | — | — | |
| Jun 29, 2021 | @ | Progressive Field | — | — | — | |
| Jun 30, 2021 | @ | Progressive Field | — | — | — | |
| Jul 2, 2021 | vs | Comerica Park | — | — | — | |
| Jul 3, 2021 | vs | Comerica Park | — | — | — | |
| Jul 4, 2021 | vs | Comerica Park | — | — | — | |
| Jul 5, 2021 | @ | Globe Life Field | — | — | — | |
| Jul 6, 2021 | @ | Globe Life Field | — | — | — | |
| Jul 7, 2021 | @ | Globe Life Field | — | — | — | |
| Jul 8, 2021 | @ | Target Field | — | — | — | |
| Jul 9, 2021 | @ | Target Field | — | — | — | |
| Jul 10, 2021 | @ | Target Field | — | — | — | |
| Jul 11, 2021 | @ | Target Field | — | — | — | |
| Jul 16, 2021 | vs | Comerica Park | — | — | — | |
| Jul 17, 2021 | vs | Comerica Park | — | — | — | |
| Jul 18, 2021 | vs | Comerica Park | — | — | — | |
| Jul 19, 2021 | vs | Comerica Park | — | — | — | |
| Jul 20, 2021 | vs | Comerica Park | — | — | — | |
| Jul 21, 2021 | vs | Comerica Park | — | — | — | |
| Jul 22, 2021 | vs | Comerica Park | — | — | — | |
| Jul 23, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| Jul 24, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| Jul 25, 2021 | @ | Ewing M. Kauffman Stadium | — | — | — | |
| Jul 26, 2021 | @ | Target Field | — | — | — | |
| Jul 27, 2021 | @ | Target Field | — | — | — | |
| Jul 28, 2021 | @ | Target Field | — | — | — | |
| Jul 29, 2021 | vs | Comerica Park | — | — | — | |
| Jul 30, 2021 | vs | Comerica Park | — | — | — | |
| Jul 31, 2021 | vs | Comerica Park | — | — | — | |
| Aug 1, 2021 | vs | Comerica Park | — | — | — | |
| Aug 3, 2021 | vs | Comerica Park | — | — | — | |
| Aug 4, 2021 | vs | Comerica Park | — | — | — | |
| Aug 5, 2021 | vs | Comerica Park | — | — | — | |
| Aug 6, 2021 | @ | Progressive Field | — | — | — | |
| Aug 7, 2021 | @ | Progressive Field | — | — | — | |
| Aug 8, 2021 | @ | Progressive Field | — | — | — | |
| Aug 10, 2021 | @ | Oriole Park at Camden Yards | — | — | — | |
| Aug 11, 2021 | @ | Oriole Park at Camden Yards | — | — | — | |
| Aug 12, 2021 | @ | Oriole Park at Camden Yards | — | — | — | |
| Aug 13, 2021 | vs | Comerica Park | — | — | — | |
| Aug 14, 2021 | vs | Comerica Park | — | — | — | |
| Aug 15, 2021 | vs | Comerica Park | — | — | — | |
| Aug 17, 2021 | vs | Comerica Park | — | — | — | |
| Aug 18, 2021 | vs | Comerica Park | — | — | — | |
| Aug 19, 2021 | vs | Comerica Park | — | — | — | |
| Aug 20, 2021 | @ | Rogers Centre | — | — | — | |
| Aug 21, 2021 | @ | Rogers Centre | — | — | — | |
| Aug 22, 2021 | @ | Rogers Centre | — | — | — | |
| Aug 24, 2021 | @ | Busch Stadium | — | — | — | |
| Aug 25, 2021 | @ | Busch Stadium | — | — | — | |
| Aug 27, 2021 | vs | Comerica Park | — | — | — | |
| Aug 28, 2021 | vs | Comerica Park | — | — | — | |
| Aug 29, 2021 | vs | Comerica Park | — | — | — | |
| Aug 31, 2021 | vs | Comerica Park | — | — | — | |
| Sep 1, 2021 | vs | Comerica Park | — | — | — | |
| Sep 2, 2021 | vs | Comerica Park | — | — | — | |
| Sep 3, 2021 | @ | Great American Ball Park | — | — | — | |
| Sep 4, 2021 | @ | Great American Ball Park | — | — | — | |
| Sep 5, 2021 | @ | Great American Ball Park | — | — | — | |
| Sep 6, 2021 | @ | PNC Park | — | — | — | |
| Sep 7, 2021 | @ | PNC Park | — | — | — | |
| Sep 8, 2021 | @ | PNC Park | — | — | — | |
| Sep 10, 2021 | vs | Comerica Park | — | — | — | |
| Sep 11, 2021 | vs | Comerica Park | — | — | — | |
| Sep 12, 2021 | vs | Comerica Park | — | — | — | |
| Sep 14, 2021 | vs | Comerica Park | — | — | — | |
| Sep 15, 2021 | vs | Comerica Park | — | — | — | |
| Sep 16, 2021 | @ | Tropicana Field | — | — | — | |
| Sep 17, 2021 | @ |
